ChCpc1, a bZIP transcription factor, coordinates amino acid synthesis and autophagy and modulates conidiation and virulence in <i>Cochliobolus heterostrophus</i>.

ABSTRACT: Cochliobolus heterostrophus, a fungal plant pathogen, is the causal agent of southern corn leaf blight. The bZIP transcription factor Cpc1 is required for response to oxidative stress and amino acid starvation in the saprobe, Neurospora crassa, and the human pathogen, Candida albicans. However, although conserved in fungal plant pathogens, Cpc1 function and regulatory mechanisms are still largely unknown. Through targeted gene deletion, we demonstrated that ChCPC1 was necessary for nitrogen assimilation and response to amino acid starvation during conidiation and the infection process. In addition, amino acid synthesis and autophagy induction were also impaired in ΔChcpc1 mutants. We found that ChCpc1 binds to the promoter region of ChARG1 and C

SUBMITTER: Yu H 

PROVIDER: S-EPMC12345223 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature