Borreliosis and doxycycline treatment disrupt gut microbiota and immune responses in nonhuman primates.

ABSTRACT: Borrelia burgdorferi (Bb) is the spirochete that causes Lyme disease (LD). Transmission to humans occurs via bites of infected Ixodes spp. ticks. Doxycycline is often used to treat LD patients, which is sometimes delayed due to current diagnostic challenges. Recently, several lines of evidence show dysbiosis of the gut microbiome in LD patients, which may be a host factor contributing to pathogenesis and symptomology but is still an understudied area in the field. To address this knowledge gap, we longitudinally compared the immune response and gut microbial composition of Japanese macaques after intradermal infection with Bb strain 297 with or without doxycycline treatment. Immunological and microbial changes were monitored longitudinally using enzyme-linked immunosorbent as

SUBMITTER: Napier EG 

PROVIDER: S-EPMC12345261 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature