The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection.

ABSTRACT: We previously identified genetic polymorphisms associated with Entamoeba histolytica-positive diarrhea at the locus containing the transcription factor, cAMP responsive element modulator (CREM). Genetic association testing in birth cohorts of Bangladeshi children showed the previously described single nucleotide polymorphisms (SNPs) at the CREM locus associated with E. histolytica-positive diarrhea were independently associated with undernutrition at 1 year of age. The reference allele for both tested SNPs was associated with lower weight-for-age z-scores (WAZ) at 1 year of age (rs2148483: 0.161 reduction in WAZ per allele, P = 0.007; rs58000832: 0.203 reduction in WAZ, P = 0.001). Small intestinal transcriptome data from Bangladeshi and American c

SUBMITTER: Brown AC 

PROVIDER: S-EPMC12345263 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature