Differential modulation of post-antibiotic colonization resistance to <i>Clostridioides difficile</i> by two probiotic <i>Lactobacillus</i> strains.

ABSTRACT: Probiotics are often consumed after antibiotic treatment to prevent antibiotic-associated diarrheal disease, most commonly caused by Clostridioides difficile. However, the impact of probiotic bacteria on the post-antibiotic gut microbiota is undetermined and often overlooked. Here, we examined the effect of a single dose of probiotic Lactobacillus acidophilus NCFM and Lactobacillus gasseri Lg-36 on colonization resistance against C. difficile in an antibiotic-treated mouse model. We found that L. acidophilus administration increased C. difficile infection and impaired the restoration of colonization resistance. In contrast, L. gasseri decreased C. difficile and promoted the return of colonization resistance, presumably through a putat

SUBMITTER: Foley MH 

PROVIDER: S-EPMC12345269 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature