EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin.

ABSTRACT: Ephrin-Bs (EFNB1-3) are ligands for members of the largest subfamily of receptor tyrosine kinases (RTKs) in humans, the EPH receptors. Interestingly, ephrin-Bs are transmembrane proteins that may also act as receptors themselves upon EPH binding, activating so-called reverse signaling pathways that are critical for multiple cellular processes. Although a number of ephrin-B signaling effectors have been identified, the molecular mechanisms underlying ephrin-B-driven cellular processes remain unresolved, suggesting that multiple signaling effectors are yet to be discovered. Here, we employed proximity labeling proteomics to delineate the proximity network of EFNB1 in steady state and under active reverse signaling conditions. This allowed us to identify 90 uncharacterized EFNB1 proximity par

SUBMITTER: Osornio-Hernandez AI 

PROVIDER: S-EPMC12345308 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature