Dual-mode immunotherapy: ultrasound responsive zinc-based nano-contract agents synergistically activate the GAS-STING pathway for enhanced tumor sono-metalloimmunotherapy.

ABSTRACT: Triple-negative breast cancer has previously been considered to a weak tumor immunogenicity. A strategy combining sono-immunotherapy and metal ion interference therapy holds promise for the tumor immune environment. 2,2-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH), functioning as a sonosensitizer, can produce alkyl radicals that can trigger sono-oxidative stress in neoplastic cells. Metal ion interference therapy has also demonstrated promise as an immunotherapy. However, the AIPH's chemical instability and the metal ions are limited by the short half-life of blood components and the lack of specificity. Herein, we developed a multifunctional nanoparticle HA/AIPH@ZIF-8 (HAZ), which incorporates hyaluronic acid (HA) specifically targeting CD44 receptors. This design aims to f

SUBMITTER: Zeng X 

PROVIDER: S-EPMC12345331 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature