HJP 272, an endothelin receptor antagonist, and its role in cancer cell migration and invasion.

ABSTRACT:

Introduction

Endothelins (ETs) are a family of versatile peptides composed of 21 amino acids with three isoforms: ET-1, ET-2, and ET-3. As the most abundant of the three isoforms, ET-1 is involved in various biological processes, such as regulation of vascular tone, humoral homeostasis, and neural crest development. However, focus is now being directed towards investigating the functions of the ET axis in the progression of different tumor types including ovarian, prostate, breast, lungs etc. HJP 272 is a novel ET_AR antagonist and while our group has previously researched its effects on lung inflammation and preterm birth, this study marks the first time its role in cancer has been explored.

Methods

We evaluated the in vitro activities of HJP 272 in the ET-1 and E

SUBMITTER: Baig N 

PROVIDER: S-EPMC12345342 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature