Myeloid loss of scaffolding protein menin promotes liver fibrosis via H3K36me3 reprogramming.

ABSTRACT: Menin, encoded by the Men1 gene, is a scaffold protein broadly involved in regulating the cell phenotype through multiple histone modifications. Here, we discuss how menin contributes to liver macrophage (MAC) and hepatic stellate cell (HSC) fate determination, placing this contribution in the context of liver fibrosis pathogenesis. We revealed that Men1 loss promoted CCL4- or high-fat diet-induced liver fibrosis. Menin regulated liver fibrogenesis primarily by modulating the activation of Kupffer cells (KCs)/HSCs rather than hepatocytes. The myeloid cell-specific knockout of Setd2 but not Kmt2a mimicked the phenotype of Men1 deletion. Menin/SETD2 suppressed the regeneration and activation of KCs by regulating IL-10 pathway activity through H3K36me3. In addition, the menin/SETD2/PPARγ comp

SUBMITTER: Han Q 

PROVIDER: S-EPMC12346064 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature