From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines.

ABSTRACT: Skeletal muscle regeneration depends on muscle stem cells, which give rise to myoblasts that drive muscle growth, repair, and maintenance. In bats-the only mammals capable of powered flight-these processes must also sustain contractile performance under extreme mechanical and metabolic stress. However, the cellular and molecular mechanisms underlying bat muscle physiology remain largely unknown. To enable mechanistic investigation of these traits, we established the first myoblast cell lines from the pectoralis muscle of Pteronotus mesoamericanus, a highly maneuverable aerial insectivore. Using both spontaneous immortalization and exogenous hTERT/CDK4 gene overexpression, we generated two stable cell lines that retain proliferative capacity and differentiate into contractile

SUBMITTER: Deng F 

PROVIDER: S-EPMC12346413 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature