In Vivo Cone Photoreceptor Topography of the Human Foveola.

ABSTRACT:

Purpose

To study in vivo cone topography of the normal human foveola.

Methods

The fovea in both eyes of 30 healthy participants was imaged with adaptive optics scanning light ophthalmoscopy. High-resolution image montages spanning two degrees of visual angle were created and cone center locations annotated. Continuous cone density maps were computed by a Voronoi cell area approach to also yield the topographical center, the cone density centroid (CDC). Cone density profiles were extracted and fit with a four-parameter decay function, D = D0 / (1 + (E/a)b)c, with D as cone density (cones/mm2), D0 as cone density at the CDC, and E as eccentricity (µm).

Results

Across eyes, D0 was 175,474 ± 20,543 cones/mm2, on average (range 136,001-216,209 cones/mm2). Density dropped a

SUBMITTER: Ameln J 

PROVIDER: S-EPMC12347159 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature