Flavoprotein Fluorescence Imaging in Stargardt Disease: Linking Metabolic Stress to Structural Damage.

ABSTRACT:

Purpose

Stargardt disease (SD) is an inherited retinal disorder that leads to progressive vision loss. Currently, no approved treatments exist. Identifying early metabolic changes in the retina could be critical for the development of new therapies. Flavoprotein fluorescence (FPF) imaging has the potential to serve as a non-invasive biomarker for detecting these early changes before structural damage is evident. Therefore, this study evaluated FPF patterns in patients with SD and correlated these findings with structural imaging modalities, specifically fundus autofluorescence (FAF) and optical coherence tomography (OCT).

Methods

This cross-sectional study enrolled 36 subjects with genetically confirmed ABCA4-associated SD between June 1, 2023, and January 31, 2024, at the U

SUBMITTER: Merle DA 

PROVIDER: S-EPMC12347185 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature