Early Peripapillary Choroidal Thinning during Myopia Development: A Potential Biomarker for Progressive Myopia Identified in Tree Shrews.

ABSTRACT:

Purpose

The purpose of this study was to investigate longitudinal thickness changes of the peripapillary tissues in tree shrew eyes with induced high myopia from juvenile age to early adulthood.

Methods

Juvenile tree shrews were randomly assigned to either a control group (16 eyes, 8 animals) or a group with binocular -10 diopter (D) lens wear (18 eyes, 9 animals). Refraction, biometry, and optical coherence tomography scans centered on the optic nerve head (ONH) were obtained weekly for 19 weeks. Data were split into three temporal phases representing myopia onset (phase I, week 1), juvenile high myopia development (phase II, weeks 2-5), and sustained high myopia into early adulthood (phase III, weeks 6-19).

Results

Most eyes in the myopia group developed and maintai

SUBMITTER: KhalafAllah MT 

PROVIDER: S-EPMC12347244 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature