Structural Features of Nucleoproteins from the Recently Discovered <i>Orthonairovirus songlingense</i> and <i>Norwavirus beijiense</i>.

ABSTRACT: The recent discovery of Orthonairovirus songlingense (SGLV) and Norwavirus beijiense (BJNV) in China has raised significant concern due to their potential to cause severe human disease. However, little is known about the structural features and function of their nucleoproteins, which play a key role in the viral life cycle. By combining small-angle X-ray scattering (SAXS) data and AlphaFold 3 simulations, we reconstructed the BJNV and SGLV nucleoprotein structures for the first time. The SGLV and BJNV nucleoproteins have structures that are broadly similar to those of Orthonairovirus haemorrhagiae (CCHFV) nucleoproteins despite low sequence similarity. Based on structural analysis, several residues located in the positively charged region of BJNV and SGLV nucleoprotein

SUBMITTER: Yanshin AO 

PROVIDER: S-EPMC12347420 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature