The Therapeutic Potential of <i>Galium verum</i> for Psoriasis: A Combined Phytochemical, In Silico, and Experimental Approach.

ABSTRACT: Psoriasis is a chronic inflammatory skin disorder involving oxidative stress and immune dysregulation. Given the limitations and adverse effects of conventional therapies, interest in natural treatments with anti-oxidant and immunomodulatory properties is increasing. This study aimed to comprehensively evaluate the therapeutic potential of Galium verum extract in an imiquimod-induced rat model of psoriasis. The extract was chemically characterized by HPLC and evaluated for anti-oxidant activity using DPPH, ABTS, and FRAP assays. Molecular docking studies targeted psoriasis-related proteins (IL-17, IL-22, IL-23, JAK2, MAPK2, NF-κB, STAT3), revealing strong binding affinities for rutin and quercetin, the extract's dominant bioactives. In vivo, 18 Wistar albino male rats were di

SUBMITTER: Daskalovic B 

PROVIDER: S-EPMC12347447 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature