Fasting-Induced Hepatic Gluconeogenesis Is Compromised In Anxa6^-/- Mice.

ABSTRACT: Maintaining constant blood glucose levels is essential for energizing glucose-dependent tissues. During the fed state, insulin lowers elevated blood glucose, while in the fasted state, glucagon maintains blood glucose levels through hepatic stimulation of fatty acid oxidation, glycogenolysis, and gluconeogenesis (GNG). The liver plays a crucial role in these metabolic adaptations. Deregulation of GNG is a hallmark of type 2 diabetes mellitus (T2DM), driven by hepatic insulin resistance, elevated glucagon levels, and excess circulating free fatty acids. The glucose metabolism of 8- to 12-week-old WT and Anxa6 knock-out (Anxa6^-/-) mice was analysed during regular feeding and fasting using indirect calorimetry, tolerance tests and biochemical analysis. Despite normal insulin-sensit

SUBMITTER: Alvarez-Guaita A 

PROVIDER: S-EPMC12349248 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature