Gut microbiota composition in early pregnancy as a diagnostic tool for gestational diabetes mellitus.

ABSTRACT: Gestational diabetes mellitus (GDM) is a metabolic disorder that poses substantial risks to both maternal and fetal health. Early intervention has been shown to effectively reduce various complications. Gut microbiota dysbiosis is strongly linked to the onset and progression of GDM and may serve as a critical early-warning biomarker. In this study, we systematically analyzed the fecal microbiota of 61 pregnant women during the first trimester using 16S rRNA sequencing. These microbial profiles were correlated with oral glucose tolerance test (OGTT) results at 24-28 weeks of gestation and clinical delivery outcomes. Our analysis identified significant differences in gut microbiota composition between GDM and healthy pregnancies, observed at both the phylum and genus levels early in gestatio

SUBMITTER: Yao W 

PROVIDER: S-EPMC12349467 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature