Project description:Spatial transcriptomics (ST) is a powerful tool for understanding tissue biology and disease mechanisms. However, the advanced data analysis and programming skills required can hinder researchers from realizing the full potential of ST. To address this, we developed spatialGE, a web application that simplifies the analysis of ST data. The application spatialGE provided a user-friendly interface that guides users without programming expertise through various analysis pipelines, including quality control, normalization, domain detection, phenotyping, and multiple spatial analyses. It also enabled comparative analysis among samples and supported various ST technologies. The utility of spatialGE was demonstrated through its application in studying the tumor microenvironment of two data sets: 10× Visium samples from a cohort of melanoma metastasis and NanoString CosMx fields of vision from a cohort of Merkel cell carcinoma samples. These results support the ability of spatialGE to identify spatial gene expression patterns that provide valuable insights into the tumor microenvironment and highlight its utility in democratizing ST data analysis for the wider scientific community.

2024-11-21 | GSE271422 | GEO

Development of a Web-Based Oxygenation Dashboard for Preterm Neonates: A Quality Improvement Initiative.

Project description: Not available

| S-EPMC11043117 | biostudies-literature

A Novel Web-Based Approach for Monitoring Biodiversity.

Project description: Not available

| S-EPMC11439740 | biostudies-literature

Biodiversity Genomics Research Practices Require Harmonising to Meet Stakeholder Needs in Conservation.

Project description: Not available

| S-EPMC12684358 | biostudies-literature

Antimicrobial resistance dashboard application for mapping environmental occurrence and resistant pathogens.

Project description: Not available