Operative performance of RAPNO DIPG imaging criteria-a study from the International DIPG/DMG Registry.

ABSTRACT:

Background

The Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group for diffuse intrinsic pontine glioma (DIPG) recently published its recommendations. We aim to test the operative performance of the RAPNO DIPG criteria imaging component by retrospectively applying it to a patient sample from the International DIPG/DMG Registry (IDIPGR).

Methods

Longitudinal MRIs for 46 patients were independently reviewed by 2 pediatric neuro-radiologists. Utilizing RAPNO DIPG imaging criteria for the pontine lesions, response was categorized as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD). The response category for each MRI was compared between 2 readers and classified as concordant if they agreed, minor discordant if one

SUBMITTER: Gorsi HS 

PROVIDER: S-EPMC12349774 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature