Project description:Spatial transcriptomics (ST) is a powerful tool for understanding tissue biology and disease mechanisms. However, the advanced data analysis and programming skills required can hinder researchers from realizing the full potential of ST. To address this, we developed spatialGE, a web application that simplifies the analysis of ST data. The application spatialGE provided a user-friendly interface that guides users without programming expertise through various analysis pipelines, including quality control, normalization, domain detection, phenotyping, and multiple spatial analyses. It also enabled comparative analysis among samples and supported various ST technologies. The utility of spatialGE was demonstrated through its application in studying the tumor microenvironment of two data sets: 10× Visium samples from a cohort of melanoma metastasis and NanoString CosMx fields of vision from a cohort of Merkel cell carcinoma samples. These results support the ability of spatialGE to identify spatial gene expression patterns that provide valuable insights into the tumor microenvironment and highlight its utility in democratizing ST data analysis for the wider scientific community.

2024-11-21 | GSE271422 | GEO

Development of a Web-Based Intervention to Support Primary Health Care Professionals in Digital Health Measurement: User-Centered Participatory Approach.

Project description: Not available

| S-EPMC12485259 | biostudies-literature

Engaging With a Web-Based Psychosocial Intervention for Psychosis: Qualitative Study of User Experiences.

Project description: Not available

| S-EPMC7334758 | biostudies-literature

A Web-Based Data Collection Platform for Multisite Randomized Behavioral Intervention Trials: Development, Key Software Features, and Results of a User Survey.

Project description: Not available

| S-EPMC5493783 | biostudies-literature