Cause of death for patients who present with primary progressive apraxia of speech.

ABSTRACT:

Background

Apraxia of speech (AOS) can be the initial and sole manifestation of neurodegenerative diseases, termed primary progressive apraxia of speech (PPAOS). These patients frequently evolve to atypical parkinsonism. There is little information to inform end of life planning and expectations.

Objective

This study explored causes of death in patients who presented with PPAOS.

Methods

Data for 29 deceased PPAOS patients and for whom cause of death data were available were reviewed.

Results

Median age at death was 76.25 years following a median disease duration of 9.78 years. Fifteen patients (52 %) succumbed to deterioration from the disease, ten (34 %) died from complications associated with dysphagia, and the remainder from a brain bleed associated with a f

SUBMITTER: Utianski RL 

PROVIDER: S-EPMC12349914 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature