AF3Complex yields improved structural predictions of protein complexes.

ABSTRACT:

Motivation

Accurate structures of protein complexes are essential for understanding biological pathway function. A previous study showed how downstream modifications to AlphaFold 2 could yield AF2Complex, a model better suited for protein complexes. Here, we introduce AF3Complex, a model equipped with both similar and novel improvements, built on AlphaFold 3.

Results

Benchmarking AF3Complex and AlphaFold 3 on a large dataset of protein complexes, it was shown that AF3Complex outperforms AlphaFold 3. Moreover, by evaluating the structures generated by AF3Complex on datasets of protein-peptide complexes and antibody-antigen complexes, it was established that AF3Complex could create high-fidelity structures for these challenging complex types. Additionally, when deployed to gen

SUBMITTER: Feldman J 

PROVIDER: S-EPMC12349917 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature