The Effect of Preexisting Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Infection Outcomes in Exposed Household Members.

ABSTRACT:

Background

We investigated the effect of preexisting antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and seasonal human coronaviruses (hCoVs) on infection outcomes in Omicron BA.1/BA.2-exposed household members from January to March 2022.

Methods

Data from a prospective household study in the Netherlands were used including 63 households with 195 household members exposed to a SARS-CoV-2 Omicron BA.1/BA.2 index case. The protocol included repeated nose-throat swab and saliva reverse-transcription polymerase chain reaction (RT-PCR) testing, paired serology, and self-reported daily symptom scoring by household members. Infection outcomes included the occurrence of secondary infections, symptom burden, and cycle threshold (Ct) value trajectories.

SUBMITTER: Westerhof I 

PROVIDER: S-EPMC12349952 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature