Genetic Susceptibility to Acute Viral Bronchiolitis.

ABSTRACT:

Background

Acute viral bronchiolitis is a major cause of infant hospitalizations worldwide. Childhood bronchiolitis is considered a risk factor for asthma, suggesting shared genetic factors and biological pathways. Genetic risk loci may provide new insights into disease pathogenesis.

Methods

We conducted a genome-wide association study to examine the genetic contributions to bronchiolitis susceptibility in the FinnGen project data. We analyzed 1465 infants hospitalized for bronchiolitis who were <2 years of age and 356 404 individuals without a history of acute lower respiratory infections.

Results

The genome-wide association study identified associations (P < 5 × 10-8) for variants in gasdermin B (GSDMB) and a missense variant in cadherin-related family member 3 (CDH

SUBMITTER: Pasanen A 

PROVIDER: S-EPMC12349955 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature