Impact of Puberty on Immune Responses to Mycobacterium tuberculosis in South African Adolescents.

ABSTRACT:

Background

As individuals progress through adolescence, their risk of tuberculosis (TB) increases, and the type of disease that develops changes, with increasing cavitary formation and parenchymal tissue destruction. While it is widely assumed that the changes in risk and disease phenotype are due to puberty exerting an impact on host immune responses to Mycobacterium tuberculosis, this relationship has been poorly studied.

Methods

Teen TB was an observational study that recruited 50 adolescents with pulmonary TB and 50 controls exposed to TB in Cape Town, South Africa. Blood was collected at baseline and again at month 2 from those with TB. Concentrations of 43 cytokines and 19 hormones were measured and compared between individuals with TB and controls, and changes were mo

SUBMITTER: Kleynhans L 

PROVIDER: S-EPMC12349956 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature