Spatial transcriptional landscape of human heart failure.

ABSTRACT:

Background and aims

Heart failure (HF) remains a significant clinical challenge due to its diverse aetiologies and complex pathophysiology. The molecular alterations specific to distinct cell types and histological patterns during HF progression are still poorly characterized. This study aimed to explore cell-type- and histology-specific gene expression profiles in cardiomyopathies.

Methods

Ninety tissue cores from 44 participants, encompassing various forms of cardiomyopathy and control samples with diverse histological features, were analysed using the GeoMx Whole Human Transcriptome Atlas. Data on cell types, clinical information, and histological features were integrated to examine gene expression profiles in cardiomyopathy.

Results

The study characterized the cel

SUBMITTER: Lee SE 

PROVIDER: S-EPMC12349961 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature