Identification of key ferroptosis-related genes and therapeutic target in nasopharyngeal carcinoma.

ABSTRACT:

Objective

Nasopharyngeal carcinoma (NPC) is a malignant tumor, but the role of ferroptosis-related genes in NPC remains unclear. This study aimed to identify ferroptosis-related therapeutic targets and explore their mechanisms in NPC.

Method

NPC datasets and ferroptosis-related genes were obtained from GEO and FerrDB, respectively. Ferroptosis-related differentially expressed genes (DEGs) were identified, and Weighted Gene Co-expression Network Analysis (WGCNA) was used to pinpoint disease-related genes. Four machine learning algorithms screened hub genes, validated by ROC curves. Functional enrichment (GSEA, GSVA), drug prediction (DGIdb), immune infiltration analysis (CIBERSORT), and single-cell RNA sequencing (scRNA-seq) were performed.

Result

From 3405 DEGs, 90 fe

SUBMITTER: Gu Y 

PROVIDER: S-EPMC12350130 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature