Electron flow in hydrogenotrophic methanogens under nickel limitation.

ABSTRACT: Methanogenic archaea are the main producers of the potent greenhouse gas methane^1,2. In the methanogenic pathway from CO₂ and H₂ studied under laboratory conditions, low-potential electrons for CO₂ reduction are generated by a flavin-based electron-bifurcation reaction catalysed by heterodisulfide reductase (Hdr) complexed with the associated [NiFe]-hydrogenase (Mvh)^3-5. F₄₂₀-reducing [NiFe]-hydrogenase (Frh) provides electrons to the methanogenic pathway through the electron carrier F₄₂₀ (ref. ⁶). Here we report that under strictly nickel-limited conditions, in which the nickel concentration is similar to those often observed in natural habitats^7-11, the production of both [NiFe]-hydrogenase

SUBMITTER: Nomura S 

PROVIDER: S-EPMC12350162 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature