In-culture coronary stenting in an <i>ex vivo</i> vascular bioreactor.

ABSTRACT:

Background

Ex vivo vascular bioreactors that enable interventions in arteries from slaughterhouse surplus hearts present valuable alternatives to animal models to test cardiovascular stents. However, the knowledge for stent implantation during ex vivo culture in slaughterhouse coronary arteries is limited. The objective of the study is two-fold: first, to determine culture settings, the time point and optimal conditions for in-culture stent implantation using surplus right coronary arteries (RCAs) from swine with known in vivo RCA diameters; and second, to implement the gained insights to culture and stent RCAs obtained from slaughterhouse hearts (unknown in vivo diameter).

Methods

Swine RCAs were mounted, cultured and stented in an ex vivo

SUBMITTER: Razzi F 

PROVIDER: S-EPMC12350248 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature