Characterization of the antagonistic secondary metabolites of <i>Paenibacillus polymyxa</i> MEZ6 against <i>Staphylococcus aureus</i>.

ABSTRACT:

Introduction

Paenibacillus polymyxa is an essential bio-control bacterium capable of producing numerous antagonistic compounds with potential usefulness. Methicillin-resistant Staphylococcus aureus (MRSA) is a significant bacterial strain that infects hospitals and communities, exhibiting considerable antibiotic resistance and posing a substantial threat to human health, thereby becoming a major bio-safety concern worldwide. The purpose of this study was to investigate the antibacterial properties and mechanisms of the secondary metabolites of P. polymyxa (MEZ6) against MRSA.

Methods

This study used microdilution procedures and growth and bactericidal kinetics studies to investigate the effects of MEZ6 metabolites on MRSA, and reverse-phase high-performa

SUBMITTER: Zhao N 

PROVIDER: S-EPMC12350257 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature