Enhancing sleep, wakefulness, and cognition with transcranial photobiomodulation: a systematic review.

ABSTRACT: Disruptions in sleep are common across clinical populations, particularly those with neurological and psychiatric disorders, making restorative sleep and sustained wakefulness a public health priority. Sleep is essential for brain function, impacting cognition in addition to serving as a critical factor in memory consolidation and healthy aging. Neuromodulation via transcranial photobiomodulation (t-PBM) increases cerebral mitochondrial activity and blood flow. These effects may underlie improvements in sleep quality and wakefulness observed after t-PBM. In this systematic review, we summarize the current literature across clinical and healthy populations, which describes t-PBM's potential to improve sleep, wakefulness, and cognition. The scope of this review also includes t-PBM's effect o

SUBMITTER: Gaggi NL 

PROVIDER: S-EPMC12350269 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature