Cardiovascular diseases in the elderly: possibilities for modulating autophagy using non-coding RNAs.

ABSTRACT: Autophagy is a crucial mechanism implicated in both aging and cardiovascular disease, which are two closely interconnected conditions. Modulation of autophagy is expected to have profound impacts on cellular aging and maintenance of cardiovascular functions under physiological or pathological conditions. Consequently, modulation of autophagy could be an effective strategy for counteracting age-induced vascular and cardiac remodelling as well as alleviating cardiovascular disease. The present review comprehensively elucidates the multifaceted impacts of autophagy on aging of the cardiovascular system. We comprehensively analyse both vascular and cardiac tissues, including vascular and cardiac malignancies, in distinct contexts. We also emphasize the significance of non-coding RNAs (ncRNAs)

SUBMITTER: Scalabrin S 

PROVIDER: S-EPMC12350270 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature