Genomic epidemiology and resistome dynamics of <i>Enterobacter</i> species in a Portuguese Open Air Laboratory: the emergence of the FRI-8 carbapenemase.

ABSTRACT: Interconnected reservoirs contribute to the global spread of antimicrobial resistance (AMR), including carbapenem- and colistin-resistant Enterobacterales, highlighting the need for a One Health approach. We assessed the genomic epidemiology, diversity and AMR mechanisms of Enterobacter spp. across interconnected human, animal, plant, and environmental reservoirs in a Portuguese Open Air Laboratory. Over a one year monitoring period, samples from 12 different compartments were collected and processed using selective media to isolate Enterobacter spp., which were subjected to antibiotic susceptibility testing, whole-genome sequencing and subsequent analyses to identify AMR determinants, characterize plasmids and phylogenetic relationships. We established a collection of

SUBMITTER: Teixeira P 

PROVIDER: S-EPMC12350302 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature