Real-world adherence trajectories to direct oral anticoagulants in naive patients with atrial fibrillation in Spain.

ABSTRACT:

Aims

This study aimed to identify adherence trajectories and associated factors in atrial fibrillation patients who initiated direct oral anticoagulant (DOAC) therapy, using population-based data from the Catalonia and Valencia regions in Spain during a 2-year follow-up.

Methods and results

Group-based trajectory modelling (GBTM) was applied to assess adherence patterns in cohorts comprising 14,641 patients in Catalonia and 13,211 in Valencia. Adherence trajectories were categorised based on prescription data, revealing three main trajectories in Valencia and five in Catalonia. Most patients in Valencia demonstrated high adherence, whereas Catalonia showed more varied patterns, including early, gradual, and late declines. Factors associated with non-adherence included high c

SUBMITTER: Leguizamo-Martinez LM 

PROVIDER: S-EPMC12350323 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature