Comparative analysis of furosemide and torsemide efficacy in 24 hours of acute heart failure admission.

ABSTRACT:

Background

Intravenous (IV) furosemide and torsemide represent a cornerstone of guideline-directed medical therapy for acute heart failure (AHF). However, the evidence regarding the superiority of each agent remains controversial.

Methods

The prospective, open-label, comparative study included 51 adult patients hospitalized due to AHF. Torsemide was administered to 25 patients (49%), and furosemide to 26 patients (51%). The primary endpoint was the change in urinary spot sodium level at 24 h, used to assess diuretic efficacy. Secondary outcomes included lung ultrasound (LUS) B-lines, clinical status evaluation based on the Borg scale, Killip-Kimball classification, and daily urine output.

Results

After 24 h of treatment, urinary sodium levels increased by an estimated

SUBMITTER: Malek-Elikowska M 

PROVIDER: S-EPMC12350330 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature