Evaluation of the protective effect of quercetin and luteolin against ciprofloxacin- and chloramphenicol-induced oxidative stress in blood cells and their impact on the microbiological activity.

ABSTRACT:

Background

The induction of oxidative stress (OS) in host cells by antibiotics (ATBs) such as ciprofloxacin (CIP) and chloramphenicol (CMP) is associated with their side effects. Flavonoids such as quercetin (Q) and luteolin (LT) could counteract the harmful effects related to OS induced by ATBs.

Purpose

The purpose of this research was to investigate the in vitro effect of CIP and CMP alone and plus Q and LT on ROS production, endogenous antioxidant defenses [superoxide dismutase (SOD) and catalase (CAT)], and protein oxidation (PO) on human leukocytes, evaluating the protective action of Q and LT on the toxicological effects of CIP and CMP.

Materials and methods

Q and LT were isolated from F. bidentis leaves and S. strombulifera fruits, respecti

SUBMITTER: Bustos PS 

PROVIDER: S-EPMC12350340 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature