Drug repurposing in traditional Chinese medicine: from empirical wisdom to modern therapeutic strategies.

ABSTRACT: Traditional Chinese medicine (TCM), with its multi-component and multi-target nature, offers rich potential for drug repurposing. Advances in systems biology, computational modeling, and high-throughput technologies have enabled systematic analysis of TCM mechanisms, facilitating in the identification of active ingredients, target interactions, and synergistic effects. However, most existing reviews focus on individual methods rather than providing an integrative translational strategy tailored to the complexity of TCM. This review addresses that gap by proposing a stage-based framework that combines mechanism analysis, preclinical validation, and clinical translation. We highlight key methodologies such as network pharmacology, multi-omics, molecular docking, and phenotypic screening, and

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12350352 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature