Enhancing prognostic accuracy in sepsis: a modified SOFA score incorporating lymphocyte count as an immune function marker.

ABSTRACT:

Background

Sepsis, characterized by organ dysfunction due to a dysregulated immune response, is diagnosed using the Sequential Organ Failure Assessment (SOFA) score, which currently lacks immune function markers. The objective of this research is to enhance the predictive precision of SOFA for sepsis by integrating lymphocyte count as an indicator of immune system functionality.

Methods

This retrospective study was based on the MIMIC-IV database. The absolute lymphocyte count (ALC) was assessed as a predictive biomarker through multivariate analysis utilizing the Cox proportional-hazards model and was integrated into a modified SOFA score (ALC-SOFA). Associations between ALC-SOFA score and mortality were assessed using Kaplan-Meier survival analysis. Predictive performance w

SUBMITTER: Huang Z 

PROVIDER: S-EPMC12350375 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature