Unveiling ammonia-induced cell death: a new frontier in clear cell renal cell carcinoma prognosis.

ABSTRACT:

Background

Clear cell renal cell carcinoma (KIRC) is the most aggressive renal carcinoma subtype of renal carcinoma, characterized by high mortality, early metastasis, and resistance to treatment. Ammonia-induced cell death (AICD) has recently been identified as a novel metabolic mechanism influencing tumor progression, yet its prognostic implication and regulatory networks in KIRC remain underexplored.

Methods

Transcriptomic and clinical information from the TCGA-KIRC cohort and the validation cohort (E-MTAB-1980) were analyzed. Differentially expressed AICD-related genes were identified through differential expression analysis, univariate Cox regression, and machine learning algorithms (LASSO, random forest, and CoxBoost). A prognostic risk model was developed via multivar

SUBMITTER: Yu P 

PROVIDER: S-EPMC12350399 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature