The impact of depression on mortality among older adult patients with hypertension: a systematic review and meta-analysis.

ABSTRACT:

Background

Depression and hypertension frequently coexist in the older adult and may jointly contribute to increased mortality and cardiovascular risk. However, the extent to which depression independently affects these outcomes remains unclear. This systematic review and meta-analysis aimed to evaluate the association between depression and all-cause mortality in older adult patients with hypertension.

Methods

We systematically searched PubMed, Embase, Cochrane Library, and Web of Science (2010-2024) for relevant cohort studies and randomized controlled trials. Pooled hazard ratios (HRs) were calculated using a random-effects model. Subgroup and sensitivity analyses were performed. The study protocol was registered in PROSPERO (CRD420251019904).

Results

Thirteen stud

SUBMITTER: Fang Z 

PROVIDER: S-EPMC12350467 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature