Effects of sevoflurane, propofol, remifentanil, and fentanyl on the endothelial proinflammatory response: an in vitro exploratory study.

ABSTRACT:

Purpose

The vascular endothelium is known to modulate the inflammatory response during surgery. Sevoflurane has been shown to protect against tumor necrosis factor alpha (TNF-α)-induced endothelial dysfunction, but the effects of other anesthetics or combinations with opioids on endothelial response are unclear.

Methods

In this in vitro study, we stimulated human umbilical vein endothelial cells with TNF-α (10 ng·mL^-1) in triplicate in three independent experiments and treated them with sevoflurane (0.8%, 2.0%, and 4.0%), propofol (2, 5, and 10 μg·mL^-1), remifentanil (2, 5, and 10 ng·mL^-1) and fentanyl (0.5, 1.5, and 5 ng·mL^-1) individually and in combinations. We evaluated the expression levels of endothelial adhesion molecules an

SUBMITTER: Tuinhout RS 

PROVIDER: S-EPMC12350494 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature