Mechanically induced development and maturation of 3D <i>in-vitro</i> organoid platform: an organotypic heterogeneous microphysiological model of patient-derived organoids with ER/PR/HER2⁺ breast cancer.

ABSTRACT:

Introduction

Breast cancer comprises diverse histological and molecular subtypes, each characterized by distinct biological behaviors and therapeutic responses. So, to unravel the biological complexity of cancer tissue, we must research it down to the heterogeneous cell level, where one can investigate and deconstruct the molecular and biochemical characteristics of various cell types (Fibroblast, Endothelial Cells, and Cancer Stem cells). Unfortunately, advancements have been hindered due to the absence of thorough methods for identifying, isolating, and cultivating all patient-derived organoids (PDOs) types from various tissues. Personalized therapy in the form of PDOs represents a promising approach to advance therapeutic outcomes. This study aims to replicate the cellular and m

SUBMITTER: Kumari M 

PROVIDER: S-EPMC12350514 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature