Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies.

ABSTRACT: The propensity of antibody-based therapies to systemically enter the brain interstitium and ameliorate pathology associated with numerous neurological maladies is precluded by the presence of the blood-brain barrier (BBB). Through distinct mechanisms, the BBB has evolved to regulate transport of essential ions, minerals, certain peptides and cells between the blood and the brain, but very restrictive otherwise. Hijacking receptor-mediated transport pathways of the BBB has proved fruitful in developing "Trojan Horse" therapeutic approaches to deliver antibody-based therapies to the brain milieu. The transferrin receptor (TfR)-mediated transcytosis pathway (RMT) is one such example where large recombinant molecules have been designed to bind to the TfR, which in turn activates the RMT pathwa

SUBMITTER: Morrison JI 

PROVIDER: S-EPMC12350589 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature