Complete spatiotemporal quantification of cardiac motion in mice through multi-view magnetic resonance imaging and super-resolution reconstruction.

ABSTRACT:

Background

Structural indices of cardiac diseases estimated via cardiac magnetic resonance imaging (CMR) have shown promise as early-stage markers. Despite the growing popularity of CMR-based myocardial strain calculations, measures of complete spatiotemporal strains (i.e., three-dimensional strains over the cardiac cycle) remain elusive, especially in mice. The high metabolic rates and rapid cardiac motion affect high-resolution imaging, thus compromising strain accuracy. We hypothesize that a super-resolution reconstruction (SRR) framework that combines low-resolution scans at multiple orientations will enhance the reliability of complete spatiotemporal strains in mice.

Methods

Multi-view cine CMR comprising short- and long-axis (SA and LA) fast low angle shot scans were o

SUBMITTER: Mukherjee T 

PROVIDER: S-EPMC12350669 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature