Design and synthesis of 3,4-<i>seco</i>-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer.

ABSTRACT:

Background

Due to the lack of effective treatment methods and targeted drugs, triple-negative breast cancer (TNBC) is not only difficult to treat clinically, but also has a poor prognosis for patients. This study aims to develop novel anti-TNBC drug candidates by designing 90 derivatives of 3,4-seco-lupane triterpene derivatives, a natural product of the genus Eleutherogenus.

Methods

Firstly, 90 derivatives were synthesized and screened, and the compound I-27 showed excellent cytotoxicity (IC₅₀=1.02 μM) for MDA-MB-231 cells for further activity verification. Then in vitro tests were carried out to detect the effects of the compound on the proliferation, migration, invasion and apoptosis of TNBC cells. With the help of transcriptomics, the mechanism of actio

SUBMITTER: Gao C 

PROVIDER: S-EPMC12351286 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature