Protective envelope dimer epitope-like antibodies are elicited against dengue virus in children after infection and vaccination.

ABSTRACT: Cross-reactive antibodies to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue virus (DENV) infection and disease. Here, we measured antibodies targeting a quaternary epitope called the envelope dimer epitope (EDE) as well as neutralizing and binding antibodies and evaluated their association with DENV infection, vaccine response, and disease outcome in dengue-vaccinated (n = 164) and dengue-unvaccinated children (n = 88) within a longitudinal cohort in Cebu, Philippines (n = 2996). Antibodies targeting EDE were prevalent and associated with broad neutralization of mature DENV1 to DENV4 virions in those with evidence of at least two prior DENV infections but were mostly absent in those with only one prior infection. S

SUBMITTER: Mpingabo PI 

PROVIDER: S-EPMC12351287 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature