Serotonin transporter deficiency, but not absence of platelet serotonin, impairs thrombus formation in a model of deep vein thrombosis.

ABSTRACT:

Background

The majority of peripheral serotonin is stored in dense granules of circulating blood platelets and released upon platelet activation. Recently, an immunomodulatory role of serotonin in inflammation has been found, influencing the recruitment of leukocytes, especially neutrophils.

Objectives

Since deep vein thrombosis creates an inflammatory milieu, called thromboinflammation, this study examined the impact of peripheral platelet serotonin on the development of venous thrombosis.

Methods

To induce deep vein thrombosis, a stenosis model of the inferior vena cava was used. Six- to 8-week-old C57BL/6 (wild-type [WT]), selective serotonin reuptake inhibitor-treated C57BL/6 (depleted serotonin pools in platelets), serotonin transporter knockout (SERT^-/-

SUBMITTER: Naber K 

PROVIDER: S-EPMC12351330 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature