Diagnostic and prognostic value of lactate metabolism-related genes in Sepsis.

ABSTRACT:

Objective

This study explored the effect of Lactate Metabolism-Related Genes (LMRGs) in the diagnosis and prognosis of Sepsis.

Methods

599 LMRGs were gained via the Molecular Signatures and GeneCards databases. Next, the authorssifted out Differently Expressed LMRGs (DE-S-LMRGs) through differential expression analysis, Protein-Protein Interactions (PPI) networks, and Weighted Gene Co-expression Network Analysis (WGCNA). Then, DE-S-LMRGs were subjected to Least-Absolute Shrinkage and Selection Operator (LASSO), gene expression patterns, Receiver Operating Characteristic (ROC), and Kaplan-Meier (K-M) survival analyses for obtaining diagnostic genes. Subsequently, the authorsyielded independent factors via univariate and multivariate COX analyses. The diagnostic genes expressi

SUBMITTER: Pan G 

PROVIDER: S-EPMC12351345 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature