Polygenic Risk, Agent Orange Exposure, and Lymphoid Neoplasms in the Veterans Affairs Million Veteran Program.

ABSTRACT:

Importance

Agent Orange (AO), a toxic herbicide mixture contaminated with carcinogenic dioxin, was widely used during the Vietnam War. Although epidemiologic evidence suggests AO exposure is associated with increased lymphoid malignant neoplasm risk, the details of this association and its potential interaction with genetic factors remain unclear.

Objective

To evaluate (1) whether AO exposure was associated with increased risk of lymphoid malignant neoplasms, (2) associations of polygenic risk scores (PRSs) in specific lymphoid malignant neoplasms, and (3) whether there was a genetic component × exposure interaction associated with increased risk of developing lymphoid malignant neoplasms.

Design, setting, and participants

A case-control study of 255 155 US veterans e

SUBMITTER: Teng X 

PROVIDER: S-EPMC12351410 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature