Association of chronic low-grade inflammation with adverse outcomes after gastrointestinal surgery: observational and Mendelian randomization study.

ABSTRACT:

Background

Although overt systemic inflammation immediately before gastrointestinal surgery has been associated with postoperative complications and mortality, it remains unclear whether baseline low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) in a non-surgery-related state is associated with the same outcomes.

Methods

This study included a subset of individuals from the Copenhagen General Population Study (CGPS) who underwent any type of gastrointestinal surgery between 2003 and 2015 after enrolment in the CGPS. Exposures were baseline hs-CRP levels (used in observational analyses) and two genetic variants that affect hs-CRP levels, namely interleukin 6 receptor (IL6R) rs4537545 and CRP rs1130864 (used in Mendelian randomization analyses), al

SUBMITTER: Orgun D 

PROVIDER: S-EPMC12351454 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature