Dopamine and Mood in Psychotic Disorders: An 18F-DOPA PET Study.

ABSTRACT:

Importance

There is limited neurobiological or trial evidence guiding treatment of comorbid affective syndromes in psychotic disorders. Given the use of dopamine-blocking antipsychotics, understanding dopamine function across these mood states is warranted.

Objective

To test for differences in dopamine synthesis capacity (Kicer) between affective syndromes across psychotic disorders and for association with psychotic symptom severity.

Design, setting, and participants

In this cross-sectional study using fluorine F 18-labeled fluorodopa (18F-DOPA) positron emission tomography (PET), individuals with first-episode psychosis and comorbid affective syndromes, including a current major depressive episode (MDE) or mixed/mania syndromes, and matched controls were recruited f

SUBMITTER: Jauhar S 

PROVIDER: S-EPMC12351467 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature